Demographic factors associated with cognitive impairment in patients with relapsing-remitting multiple sclerosis: BICAMS battery analysis
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https://doi.org/10.47606/ACVEN/MV0289Resumen
Introduction: Multiple sclerosis is a chronic, immune-mediated disease of the central nervous system that frequently leads to cognitive decline, significantly impacting patients’ quality of life and functionality. Understanding how demographic variables interact with cognitive performance is essential to guide clinical evaluation and therapeutic strategies Objective: To determine the relationship between demographic factors and cognitive impairment in patients with relapsing-remitting multiple sclerosis at the Teodoro Maldonado Carbo Hospital, Guayaquil-Ecuador, 2017-2022. Methods: A correlational, non-experimental, descriptive study that included 145 patients with relapsing-remitting multiple sclerosis. Demographic factors (age, sex, level of education) and cognitive impairment were evaluated using the BICAMS (Brief International Cognitive Assessment for Multiple Sclerosis) battery. Pearson's Chi² tests was used to establish statistical relationships. Results: The mean age was 40.75±13.46 years, with a slight female predominance (52%). Cognitive impairment occurred in 6.2-10.3% depending on the domain evaluated. A statistically significant association was found between age and cognitive impairment measured by BVMTR (p=0.007). The level of schooling showed a significant association with BVMTR (p<0.001) and CVLT-II (p=0.033). No significant association between sex and cognitive impairment was observed in any test (p>0.05). Conclusions: Demographic factors age and level of education are significant predictors of cognitive impairment in patients with relapsing-remitting multiple sclerosis, while sex showed no association. These findings suggest the importance of considering cognitive reserve in neuropsychological assessment.
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Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, et al. Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition. Mult Scler. 2020; 26(14):1816-21. DOI: 10.1177/1352458520970841
Sumowski JF, Benedict R, Enzinger C, Filippi M, Geurts JJ, Hamalainen P, et al. Cognition in multiple sclerosis: State of the field and priorities for the future. Neurology. 2018; 90(6):278-88. DOI: 10.1212/WNL.0000000000004977
Askari M, Mirmosayyeb O, Fattahi F, Ghoshouni H, Moases Ghaffary E, Shaygannejad V, et al. Prevalence of cognitive impairment (CI) in patients with multiple sclerosis (MS): A systematic review and meta-analysis. Caspian J Intern Med. 2024; 15(3):392-413. DOI: 10.22088/cjim.15.3.392
Potticary H, Langdon D. A Systematic Review and Meta-Analysis of the Brief Cognitive Assessment for Multiple Sclerosis (BICAMS) International Validations. J Clin Med. 2023; 12(2):703. DOI: 10.3390/jcm12020703
Brochet B, Ruet A. Cognitive impairment in multiple sclerosis with regards to disease duration and clinical phenotypes. Front Neurol. 2019;10:261. DOI: 10.3389/fneur.2019.00261
Deluca GC, Yates RL, Beale H, Morrow SA. Cognitive Impairment in Multiple Sclerosis: Clinical, Radiologic and Pathologic Insights. Brain Pathol. 2015; 25(1):79-98. DOI: 10.1111/bpa.12220
Langdon DW, Amato MP, Boringa J, Brochet B, Foley F, Fredrikson S, et al. Recommendations for a Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). Mult Scler. 2012; 18(6):891-8. DOI: 10.1177/1352458511431076
Corfield F, Langdon D. A Systematic Review and Meta-Analysis of the Brief Cognitive Assessment for Multiple Sclerosis (BICAMS). Neurol Ther. 2018; 7(2):287-306. DOI: 10.1007/s40120-018-0102-3
Sadigh-Eteghad S, Abbasi Garravnd N, Feizollahi M, Talebi M. The Expanded Disability Status Scale Score and Demographic Indexes Are Correlated with the Severity of Cognitive Impairment in Multiple Sclerosis Patients. J Clin Neurol. 2021; 17(1):113-20. DOI: 10.3988/jcn.2021.17.1.113
Kalb R, Beier M, Benedict RH, Charvet L, Costello K, Feinstein A, et al. Recommendations for cognitive screening and management in multiple sclerosis care. Mult Scler. 2018; 24(13):1665-80. DOI: 10.1177/1352458518794632
Chen MH, Chiaravalloti ND, DeLuca J. Neurological update: cognitive rehabilitation in multiple sclerosis. J Neurol. 2021; 268(12):4908-14. DOI: 10.1007/s00415-021-10618-2
Correa-Díaz EP, Jácome-Sánchez EC, Torres Herrán GE, Buestán Zumba ME, Altamirano-Brito MJ, Caiza-Zambrano FJ, et al. The Epidemiological and Clinical Profile of Multiple Sclerosis in Ecuador. Rev Ecuat Neurol. 2019; 28(2):59-70. Available in: http://scielo.senescyt.gob.ec/scielo.php?script=sci_abstract&pid=S2631-25812019000200059
Abad P, Pérez M, Castro E, Alarcón T, Santibáñez R, Díaz F. Prevalence of multiple sclerosis in Ecuador. Neurology. 2010; 25(5):309-13. DOI: 10.1016/S0213-4853(10)00021-6
Renner A, Baetge SJ, Filser M, Penner IK, Ullrich S, Lassek C, et al. Characterizing cognitive deficits and potential predictors in multiple sclerosis: A large nationwide study applying Brief International Cognitive Assessment for Multiple Sclerosis in standard clinical care. J Neuropsychol. 2020; 14(3):347-69. DOI: 10.1111/jnp.12202
Alarcón AN, Ayala OD, García JR, Montañés P. Validation of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) in a Colombian Population. Mult Scler Relat Disord. 2020;42:102072. DOI: 10.1016/j.msard.2020.102072
Damasceno A, Pimentel-Silva LR, Damasceno BP, Cendes F. Cognitive trajectories in relapsing-remitting multiple sclerosis: A longitudinal 6-year study. Mult Scler. 2020; 26(13):1740-51. DOI: 10.1177/1352458519873707
Virgilio E, Vecchio D, Crespi I, Puricelli C, Barbero P, Galli G, et al. Cerebrospinal fluid biomarkers and cognitive functions at multiple sclerosis diagnosis. J Neurol. 2022; 269(6):3249-57. DOI: 10.1007/s00415-021-10945-4
Mashayekhi F, Sadigh-Eteghad S, Naseri A, Bagheri S, Sadeghloo T, Shahveisi K, et al. ApoE4-positive multiple sclerosis patients are more likely to have cognitive impairment: a cross-sectional study. Neurol Sci. 2022; 43(2):1189-96. DOI: 10.1007/s10072-021-05383-z
Benedict RH, DeLuca J, Phillips G, LaRocca N, Hudson LD, Rudick R, et al. Validity of the Symbol Digit Modalities Test as a cognition performance outcome measure for multiple sclerosis. Mult Scler. 2017; 23(5):721-33. DOI: 10.1177/1352458517690821
Elshebawy H, Fahmy EM, Elfayoumy NM, Abd Elazeim AH, Khairy A. Clinical predictors to cognitive impairment in multiple sclerosis patients. Egypt J Neurol Psychiatry Neurosurg. 2021;57:38. DOI: 10.1186/s41983-021-00292-6
Valdivia-Tangarife ER, Morlett-Paredes A, Villaseñor-Cabrera T, Mireles-Ramírez MA, Cortés-Enríquez F, Macías-Islas MÁ. Validation of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) in individuals with multiple sclerosis from Mexico. Mult Scler Relat Disord. 2024;83:105451. DOI: 10.1016/j.msard.2024.105451
Darwish H, Zeinoun P, Farran N, Ghusn H, Yamout B, Khoury SJ. The Brief International Cognitive Assessment in Multiple Sclerosis (BICAMS): Validation in Arabic and Lebanese Normative Values. J Int Neuropsychol Soc. 2022; 28(1):94-103. DOI: 10.1017/S1355617721000102
Evdoshenko E, Laskova K, Shumilina M, Nekrashevich E, Andreeva M, Neofidov N, et al. Validation of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) in the Russian Population. J Int Neuropsychol Soc. 2022; 28(5):503-10. DOI: 10.1017/S1355617721000722
Marstrand L, Østerberg O, Walsted T, Skov AC, Schreiber KI, Sellebjerg F. Brief international cognitive assessment for multiple sclerosis (BICAMS): A danish validation study of sensitivity in early stages of MS. Mult Scler Relat Disord. 2020;37:101458. DOI: 10.1016/j.msard.2019.101458
Sousa C, Rigueiro-Neves M, Miranda T, Alegria P, Vale J, Passos AM, et al. Validation of the brief international cognitive assessment for multiple sclerosis (BICAMS) in the Portuguese population with multiple sclerosis. BMC Neurol. 2018; 18(1):172. DOI: 10.1186/s12883-018-1175-4
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Derechos de autor 2025 Rosa Elena Cepeda Escalante, Víctor Manuel Reyes, María Gabriela Acuña Chong, Francia Ivonne Molina Villacís
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
